BelvaRafenib 是一种有效的泛 Raf 抑制剂，具有抗肿瘤活性，对 B-Raf、B-Rafv600E和C-Raf 的IC50值分别为 56、7 和 5 nM。

Belvarafenib is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

Belvarafenib ?is a potent and pan RAF inhibitor with antineoplastic activity.?The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.?It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively.

1446113-23-0

C23H16ClFN6OS

478.93

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years