AG 126 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶p42MAPK(ERK2) 的激活。

The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 >100 μM).

118409-62-4

C10H5N3O3

215.168

Tyrphostin AG126;AG 126

DMSO:100 mg/mL (464.75 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years