ARS-1620 是 K-RasG12C 的共价抑制剂，具有理想的药代动力学。

ARS-1620 is a covalent inhibitor of K-RASG12C.

ARS-1620 (200 mg/kg) induces tumor regression in a MIA-PaCa2, but not an H441, mouse xenograft model.?It also decreases tumor volume in patient-derived xenograft (PDX) mouse models expressing K-RASG12C, but not K-RASG12D or wild-type K-RAS.

1698055-85-4

C21H17ClF2N4O2

430.84

DMSO:53 mg/mL (123.02 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years