K-Ras(G12C) inhibitor 12是一种K-Ras(G12C)抑制剂，作用于H1792细胞，EC50为0.32 μM。

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).

K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]

1469337-95-8

C15H17ClIN3O3

449.67

DMSO:26 mg/mL (57.8 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years