LY-2584702 free base 是一种选择性的 ATP 竞争性 p70S6K 抑制剂，IC50为 4 nM，对S6K1的IC50为 2 nM，用于研究癌症治疗的试验。

LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2].

LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

1082949-67-4

C21H19F4N7

445.426

DMSO:1 mg/mL(2.24 mM),warmed
DMSO:10 mM,warmed with 50oC water bath
Powder: -20°C for 3 years
In solvent: -80°C for 2 years