Gossypin 是一种从Hibiscus vitifolius中分离得到的黄酮，能够抑制NF-Κb和 NF-Κb 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。

Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis.

Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities.?However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated.?gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth.?Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration.?Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins.?Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein.?Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer[2].

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