PI3Kα/mTOR-IN-1是一种有效的PI3Kβ/mTOR双重抑制剂。在细胞测定中，PI3Kα/mTOR-IN-1的IC50为7nM，在无细胞测定中mTOR和PI3Kβ的Kis分别为12.5nM和10.6nM。

PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.

PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases[1].

PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1].

1013098-90-2

C16H18N6O

310.35

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years