Sitagliptin phosphate monohydrate 是一种有效的 DPP-IV 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。

Sitagliptin phosphate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3]

654671-77-9

C16H15F6N5O·H3PO4·H2O

523.32

MK-0431 phosphate monohydrate;西他列汀磷酸盐一水合物;MK-0431

DMSO:93 mg/mL (177.7 mM)
Ethanol:<1 mgml
H2O:38 mg/mL (72.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years