RA190 能够与泛素受体 RPN13 的半胱氨酸 88 共价结合，并抑制蛋白酶体功能。

RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.

Multiple myeloma (MM) lines, even those resistant to bortezomib, are sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilizes targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially kills HPV-transformed cells.

RA190 administration profoundly reduces growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retards HPV16+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses.

1617495-03-0

C28H23Cl5N2O2

596.76

DMSO:95mg/ml (159.19 Mm)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years