RA375 是一种 RPN13（26S 蛋白酶体调节亚基）抑制剂。 RA375 激活 UPR 信号、ROS 产生和细胞凋亡。 RA375 对癌症细胞的活性比 RA190 高 10 倍，这反映了它的硝基环取代基和氯乙酰胺弹头的添加。

RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.

RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].

T36902

C30H25ClN4O7

588.99

RA375

DMSO:125 mg/mL (212.22 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years