ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin抑制作用微弱，IC50分别为 32 μM 和 >100 μM。

ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively).

1644342-14-2

C21H23BrN6O5S

551.41

DMSO:250 mg/mL (453.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years