TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).

TAS4464 treatment inhibits cullin neddylation. TAS4464 induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.

1848959-10-3

C21H23FN6O6S

506.51

DMSO:125 mg/mL (246.79 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years