DKM 2-93是相对选择性UBA5抑制剂，IC50=430 μM。

DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).

Covalent ligand DKM 2-93 that impairs pancreatic cancer cell survival and in vivo tumor growth through covalently modifying the catalytic cysteine of the ubiquitin-like modifier activating enzyme 5 (UBA5), thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins.

65836-72-8

C11H14ClNO3

243.69

DMSO:150 mg/mL (615.54 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years