NAE-IN-M22 是一种选择性可逆的 NEDD8 激活酶抑制剂。 它抑制多种癌细胞系并诱导 A549 细胞凋亡，还可以在体内抑制肿瘤生长。

NAE-IN-M22 is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.

NAE-IN-M22 as a selective NAE inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells.

NAE-IN-M22 as a selective NAE inhibitor. M22 is reversible for NAE, inhibits multiple cancer cell lines with GI50 values in the low micromolar range, and induces apoptosis in A549 cells.

864420-54-2

C20H24Cl2N2

363.33

NEDD8 inhibitor M22

DMSO:250 mg/mL (688.10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years