Lycopodine (100, 200 μg/mL;?24 hours) increases level of Bax and decreases the mitochondrial cytochrome c. This is followed by an increase in expression of cytochrome c in cytosolic fraction.?Lycopodine also cleaves the caspase-3 in the total cell lysate, while the expression of Bcl-2 is down regulated[2].Lycopodine (5.22-78.3 μg/mL;?12 hours) has 50% viability at 57.62±0.086 μg/mL and 51.46±1.43 μg/mL for PC3 and LnCaP, respectively[1].?Treated with Lycopodine (74-222 mM;?12 hours), the apoptotic index is with respect to the gradual increase in doses for the PC3 and LnCaP cells[1].?Lycopodine (74-222 mM;?12 hours) induces cell cycle arrest at G0/G1 phase in PC3 and LnCaP cells[1].?Lycopodine (0-200 μg/mL;?48 hours) shows cytotoxicity to HeLa cells in a dose and time dependent manner.?However, Lycopodine shows minimal cytotoxic effects in normal peripheral blood mononuclear cells (PBMC) even at the highest dose (200 μg/mL)[2].

466-61-5

C16H25NO

247.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years