BHQ 是一种有效和选择性的内质网 Ca2+-ATPase 抑制剂，可调节5-LO以及COX-2活性，IC50分别为 1.8 和 14.1 μM。

BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.

BHQ shifted the voltage dependence of the steady-state inactivation curve to more negative potentials by 7 mV in the mid-potential of the curve, without affecting the activation curve as well as the time course of I(Ca(L)) inactivation.?Preincubation of the cells either with 10 microM cyclopiazonic acid, a SERCA inhibitor, or with 3 mM diethyldithiocarbamate, an inhibitor of intracellular superoxide dismutase (SOD), did not modify BHQ inhibition of I(Ca(L)).?On the contrary, this effect was no longer evident when SOD (250 u ml(-1)) was added to the perfusion medium.?Either in the presence or in the absence of cells, BHQ gave rise to superoxide anion formation, which was markedly inhibited by the addition of SOD.At micromolar concentrations, BHQ inhibits vascular I(Ca(L)) by giving rise to the formation of superoxide anion which in turn impairs the channel function.

88-58-4

C14H22O2

222.328

BHQ;2,5-二特丁基对苯二酚

DMSO:10mg/mL(44.98mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years