CCF0058981 (CCF981) 是3-氯苯基类似物，是一种非共价SARS-CoV-2 3CLpro(SC2)抑制剂，IC50为 68 nM。CCF0058981 抑制SC1 (SARS-CoV-1 3CLpro)，IC50为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。

CCF0058981 (CCF981) is a 3-chlorophenyl analogue which is a noncovalent SARS-CoV-2 3CL pro (SC2) inhibitor with an IC 50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CL pro ) with an IC 50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research [1].

CCF0058981 (CCF981) exhibits cytopathic effect (CPE) inhibition (EC 50 =497 nM) and plaque reduction (EC 50 =558 nM) in vitro viral replication [1]. CCF0058981 has the 50% cytotoxic concentration (CC 50 ) in the CPE antiviral assay of >50 μM [1]. CCF0058981 has a T 1/2 of 21.1 min, a CL lnt of 141 mL/min kg in Human liver microsomes [1].

2708934-53-4

C24H19ClN6O

442.9

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years