L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。

L-Allylglycine is a potent inhibitor of the synthetic enzyme for GABA, glutamic acid decarboxylase.

L-allylglycine inhibits glutamic acid decarboxylase(GAD) only when used at high concentrations (1-80 mM). The more potent in vivo activity can be attributed to metabolic conversion of L-allylglycine to 2-keto-4-pentanoic acid, a more potent convulsant and GAD inhibitor[1].

The stereoisomers of allylglycine were injected into the posterior hypothalamus at a site also shown to be reactive to bicuculline. Injection of L-allylglycine but not D-allylglycine caused substantial increases in heart rate but only slight increases in blood pressure[1].

16338-48-0

C5H9NO2

115.13

PBS (pH 7.2):10 mg/mL
Ethanol:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years