NCT501 是一种茶碱类化合物，有效抑制醛脱氢酶 1A1(ALDH1A1), 抑制 hALDH1A1 IC50为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时,IC50值 >57 UM)。

NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.

In Caco-2 cell line, NCT-501 exhibits excellent permeability. [1]

In CD1 Mice, NCT-501 is well absorbed and distributed but rapidly metabolized and/or excreted. [1]

1802088-50-1

C21H32N6O3

416.52

NCT501

Ethanol:24 mg/mL (57.6 mM)
DMSO:30 mg/mL (72 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years