Mahanimbine suppresses the progression of high-fat diet (HFD)-induced metabolic complications in mice. Mahanimbine is an orally active alkaloid from curry leaves.

Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin-responsive genes in liver and adipose tissue. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine (2-4 mg/kg; p.o.; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).

21104-28-9

C23H25NO

331.45

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years