UCPH101 是一种兴奋性氨基酸转运子亚型 1 (EAAT1) 的抑制剂(IC50:0.66 μM)。

UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.

A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048). UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102.

1118460-77-7

C27H22N2O3

422.484

UCPH 101

DMSO:10.6 mg/mL(25 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years