Sulfaphenazole是一种CYP2C9的特异性抑制剂，抑制CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应，增加AP-1的氧化应激和激活。

Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

526-08-9

C15H14N4O2S

314.36

磺胺苯吡唑;Plisulfan;Depotsulfonamide;Raziosulfa;Depocid

Ethanol:0.5 mg/mL
DMSO:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years