HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂，可抑制 Kasumi-1 细胞的生长，IC50值为2.3 μM。

HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).

The heat shock protein 70 (Hsp70) is a molecular chaperone that plays an important function in protein homeostasis and in cell signaling as well as survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is further thought to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life[1].

1268273-90-0

C24H28N6O2S

464.59

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years