Gisadenafil 是一种特异性磷酸二酯酶 5 (PDE5) 抑制剂，IC50 为 3.6 nM，可防止 cGMP 降解。

Gisadenafil is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.

In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2].

In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2].

334826-98-1

C23H33N7O5S

519.62

吉沙那非;UK-369003

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years