Ro20-1724 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其Ki=1930 nM，具有神经保护作用。

Ro20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.

RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress[2].

29925-17-5

C15H22N2O3

278.35

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro20-1724;Ro-20-1724

Ethanol:50 mg/Ml(179.63 mM)
DMSO:50 mg/Ml(179.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years