BPN14770 是选择性磷酸二酯酶 4D(PDE4D)变构抑制剂，能够抑制 PDE4D7 (IC50:7.8 nM) 与 PDE4D3 (IC50:7.4 nM)。

BPN14770 is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).

BPN14770 increases brain cAMP increases phosphorylation of CREB and increases the production of brain-derived neurotrophic factor (BDNF) in the hippocampus [1]. BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition at doses above 0.3 mg/kg [2].

1606974-33-7

C21H15ClF3NO2

405.8

BPN14770

DMSO:260 mg/mL (640.71 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years