Zaprinast 是一种 cGMP 选择性的磷酸二酯酶(PDE)抑制剂，是一种GPR35激动剂，对大鼠 GPR35 有很强的激活作用，对人 GPR35 有一定的激活作用。它通过抗增殖和促凋亡作用，减少血管的重构。

Zaprinast was an unsuccessful Clinicalal drug candidate that was a precursor to the chemically related PDE5 inhibitors, such as sildenafil (Viagra), which successfully reached the market.

37762-06-4

C13H13N5O2

271.28

DMSO:30 mg/ml (110.59 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years