CDC25 Phosphatase Inhibitor I 是一种CDC25 Phosphatase家族的有效的、不可逆的、选择性的泛抑制剂。它显示出比 CD45 酪氨酸磷酸酶高约 20 倍的选择性。

BN82002 is a synthetic inhibitor of CDC25 phophatases

The effect of BN82002 on cell proliferation is evaluated in vitro on several human tumor cell lines. Menadione is used as a control, that has been reported to inhibit cell proliferation. All of the examined cell lines are sensitive to BN82002 and Menadione in a concentration-dependent manner in the low micromolar range. The most sensitive is the pancreatic cancer cell line MIA PaCa-2 with an IC50 of 7.2 μM, and the less sensitive cell line is the colon cancer HT-29 with an IC50 of 32.6 μM. The range of activity is very similar to the one observed with menadione (5-15 μM). It is also showed that 50 μM BN82002 is a concentration that fully inhibits cell proliferation, the cell cycle distribution is only modestly affected with a slight decrease in S phase and an increase in cells containing both a G1 and a G2 DNA content, suggesting that the cells treated with BN82002 are arrested at various stages of the cell cycle.

396073-89-5

C19H25N3O4

359.426

CDC25 Phosphatase Inhibitor I

DMSO:150 mg/mL (417.34 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years