CPDA是新型 SH2 domain-containing iNOSitol Phosphatase 2 抑制剂，能够作用于3T3-L1脂肪细胞，改善胰岛素抗性。

CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).

CPDA enhances insulin signaling. CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice.

CPDA greatly improves abnormal glucose metabolism in diabetic animals. In db/db mice, CPDA improves abnormal glucose metabolism.

1415834-63-7

C20H15ClF2N2O2

388.8

DMSO:50 mg/mL (128.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years