Auten-99 HBr 是新型肌管蛋白磷酸酶Jumpy( MTMR14) 的抑制剂，可通过血脑屏障，具有强大的神经保护作用。

Auten-99 HBr is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson’s and Huntington’s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.

1049780-58-6

C17H15BrN2S

359.28

Auten-99;Auten-99 hydrochloride. Auten-99 HBr;Auten99;Auten 99

DMSO:11 mg/ml (30.62 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years