PTP Inhibitor I 是一种PTP1B的有效抑制剂，其Ki=42 μM。

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].

Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis.

2491-38-5

C8H7BrO2

215.046

SHP-1 Inhibitor II;4-Hydroxyphenacyl bromide;2-溴-4'-羟基苯乙酮;PTP Inhibitor I;α-Bromo-4-hydroxyacetophenone

DMSO:20 mg/mL
H2O:Insoluble
Ethanol:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years