BIA 是一种 cdc25B 抑制剂。

BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.

The proliferation and cell viability of all cell lines were inhibited by treatment with 5?μM BIA.The IC50 values at 3 days were 1.7?±?0.1?μM for HT1080, 2.6?±?0.4?μM for MCF cells, 2.6?±?0.5?μM for MDA-MB-231 cells, and 2.4?±?0.4?μM for SKBR3 cells. Moreover, HT1080 cells stably overexpressing TMBIM6 showed high sensitivity to BIA[1].BIA decreases the binding between TMBIM6 and mTORC2, we performed a gel filtration assay in TMBIM6-overexpressing HT1080 cells after treatment with BIA during 24?h[1].

134271-74-2

C15H12N2O3

268.27

DMSO:65 mg/ml (242.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years