Tacrolimus hydrate是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。

Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.

109581-93-3

C44H71NO13

822.03

LCP-Tacro;他克莫司一水合物;FK 506;FR900506;Tacrolimus hydrate;Prograf;FK-506;FR 900506

DMSO:100 mg/mL (121.65 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years