Sephin1 是 GADD34 (PPP1R15A) 的选择性抑制剂，这是一种应激诱导的蛋白磷酸酶 1 复合物调节亚基，可将 eIF2α 去磷酸化。

Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α

Sephin1 leads to a strong attenuation of neuronal excitotoxicity independently of the integrated stress response[1].

Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis[2].

13098-73-2

C8H9ClN4

196.64

IFB-088;NSC 65390

H2O:insoluble
DMSO:7mg/ml(35.60mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years