Perhexiline maleate是肉碱棕榈酰转移酶1抑制剂，对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。

Perhexiline maleate is a potent inhibitor of carnitine palmitoyltransferase 1 (CPT 1) (rat heart and liver CPT 1 with IC50s of 77 and 148 μM , respectively).

Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells[2].

The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO.

6724-53-4

C23H39NO4

393.56

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years