NL-1 是一种mitoNEET抑制剂，具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长，IC50分别为 47.35 μM 和 56.26 μM。

NL-1 is a mitoNEET inhibitor with antileukemic effect.

NL-1 Reduced the number of viable cells in REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines, in a concentration-dependent manner.

NL-1 showed antileukemic activity in an in vivo mouse ALL model

Cell Line:REH, REH/Ara-C and ALL (SUP-B15, TOM-1, JM1, NALM-1, NALM-6, BV-173) cell lines. Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, 100 μM.Incubation Time:72 hours

Animal Model:10 female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (6-8 month old) injected with TOM-1 ALL cells. Dosage:10 mg/kg.Administration:Intraperitoneal injection; daily; for 5 days

188532-26-5

C18H25NO3S

335.46

DMSO:250 mg/mL (745.25 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years