FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM.

FM26 ( 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells.

2407981-35-3

C22H15ClF3N3O3

461.82

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years