TPPB 是可渗透细胞的苯并内酰胺衍生蛋白的激酶 C 激活剂，Ki值为11.9 nM。

TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).

TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2].

TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1].

497259-23-1

C27H30F3N3O3

501.54

DMSO:125 mg/mL (249.23 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years