Hispidin 是来自裂蹄木层孔菌的酚类天然产物，是一种PKC抑制剂，具有很强的抗氧化、抗癌、抗糖尿病和抗痴呆作用。

Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties

Hispidin from P. linteus exhibited quenching effects against DPPH radicals, superoxide radicals, and hydrogen peroxide in a dose-dependent manner. Intracellular reactive oxygen species scavenging activity of hispidin was approximately 55% at a concentration of 30 μM. In addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. These combined results indicate that hispidin may act as an antidiabetic and that this property occurs through preventing β-cells from the toxic action of reactive oxygen species in diabetes[1].Hispidin inhibits protein kinase C β (PKCβ ; IC50 = 2 μM) with no activity against alkaline phosphatase[2]

555-55-5

C13H10O5

246.218

6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years