您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > ZLN024
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ZLN024
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZLN024图片
CAS NO:723249-01-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
ZLN024 是有效的AMPK变构激活剂,直接激活重组 AMPK α1β1γ1,AMPK α2β1γ1,AMPK α1β2γ1 和 AMPK α2β2γ1 异源三聚体,EC50分别为 0.42 μM,0.95 μM,1.1 μM 和 0.13 μM。

产品描述

ZLN024 is an activator of AMPK allosteric. ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

体外活性

ZLN024 allosterically stimulates active AMPK heterotrimers and the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312). ZLN024 increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 μM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM. ZLN024 also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 μM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 μM.

体内活性

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased.

Cas No.

723249-01-2

分子式

C13H13BrN2OS

分子量

325.22

储存和溶解度

DMSO:50 mg/ml (153.74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years