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Centrinone-B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Centrinone-B图片
CAS NO:1798871-31-4
包装:50 mg
市场价:8877元

产品名称
LCR-323
产品介绍

产品描述

Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).

体外活性

Centrinone-B (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except for p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Centrinone-B slightly binds to Aurora A and Aurora B (Kis: 1239 nM and 5597.14 nM). Centrinone-B exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes [1]. Inhibition of PLK4 by Centrinone-B also induces apoptosis in human melanoma cell lines [2].

Cas No.

1798871-31-4

分子式

C27H27F2N7O5S2

分子量

631.67

别名

LCR-323

储存和溶解度

DMSO:25 mg/mL (39.58 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years