Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

1847485-91-9

C25H22ClFN6O2S

525

ABT-348 hydrochloride

DMSO:41.67 mg/mL (79.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years