CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide range of cancer cells.

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B (IC50s: 92 nM and 1000 nM).

T10840

C29H43Cl3N4O3

602.04

CM-579 trihydrochloride

DMSO:125 mg/mL (207.63 mM),Need ultrasonic
H2O:37.5 mg/mL (62.29 mM),Need ultrasonic
MEthanol:75 mg/mL (124.58 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years