UNC926 hydrochloride 是一种甲基赖氨酸 (Kme) 阅读器结构域抑制剂，可特异性抑制L3MBTL1，其IC50为 3.9 μM。

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7[1]. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1[1].

1782573-49-2

C16H22BrClN2O

373.72

DMSO:150 mg/mL (444.77 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years