TP-064 是选择性蛋白精氨酸甲基转移酶 4 抑制剂 ，IC50小于10 nM，具有抗癌活性。它抑制 BAF155 和 MED12 的二甲基化，IC50为 340 和 43 nM。它对于 PRMT6 的IC50为 1.3 μM。

TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50< 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell.

2080306-20-1

C28H34N4O2

458.6

TP 064

DMSO:125mg/mL (272.57mM),ultrasonic and warming and heat to 60℃
Powder: -20°C for 3 years
In solvent: -80°C for 2 years