EPZ011989是一种高选择性可口服的EZH2抑制剂，对wt EZH2以及EZH2突变型Ki值<3nM。

EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki< 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.

1598383-40-4

C35H51N5O4

605.824

DMSO:10 mM
Ethanol:100 mg/mL (155.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years