(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.

Treatment of IDH1-WT HeLa cells with (2R)-octyl-α-hydroxyglutaric acid (a modified form of 2-hydroxyglutaric acid with high cellular uptake) results in a dose-dependent DSB in log phase cells increase. It has been used to examine the contribution of D-2-hydroxyglutarate to the oxidative mitochondrial process of IDH1 mutant cancer cells.

1391194-67-4

C13H24O5

260.33

(2R)-Octyl-2-HG

DMSO:100 mg/mL (384.13 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years