eCF506 是一种高效的、口服具有活力的非受体酪氨酸激酶Src抑制剂，其IC50<0.5 nM。

eCF506 is a potent and selective inhibitor of SRC (IC50< 0.5 nM)

eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL.?eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.

1914078-41-3

C26H38N8O3

510.643

DMSO:62.5 mg/mL (122.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years