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Tirbanibulin Mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tirbanibulin Mesylate图片
CAS NO:1080645-95-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
KX01 Mesylate
KX2-391 Mesylate
产品介绍
Tirbanibulin Mesylate 是一种 Src 抑制剂,靶向 Src 的肽底物位点。在肿瘤细胞中,GI50值为 9-60 nM。

产品描述

Tirbanibulin Mesylate is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

体外活性

Tirbanibulin Mesylate is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin Mesylate displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines [1]. Tirbanibulin Mesylate is evaluated in engineered Src drove cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively [2].

体内活性

In pre-clinical animal models of cancer, Tirbanibulin Mesylate (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis [2].

Cas No.

1080645-95-9

分子式

C27H33N3O6S

分子量

527.63

别名

KX01 Mesylate;KX2-391 Mesylate

储存和溶解度

DMSO:99 mg/mL (187.63 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years