ZK756326 dihydrochloride is a agonist of nonpeptide chemokine receptor for the CC chemokine receptor CCR8.

ZK 756326 inhibits the binding of the CCR8 ligand I-309 (CCL1)(IC50 of 1.8 μM). ZK 756326 is a CCR8 full agonist, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. ZK 756326 stimulates extracellular acidification in cells expressing human CCR8. In these assays, ZK 756326 is tested at 50 μM for inhibition of radiolabeled ligand binding. At this concentration, ZK 756326 shows >28 fold specificity for CCR8 compared with 26 other GPCRs, all with IC50 values of >50 μM.

1780259-94-0

C21H30Cl2N2O3

429.38

DMSO:6 mg/mL (13.97 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years